Author

P. R. Cook

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Bioengineering· 4

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 3 Approach:statistical model· 3 Approach:biophysical modeling· 2 Research Focus:cell-cell communication· 2 Assay:ChIP-seq· 2

Frequent Co-Authors

D. Marenduzzo· 5 shared D. Michieletto· 3 shared E. Walsh· 3 shared A. Papantonis· 2 shared C. A. Brackley· 2 shared C. Deroy· 2 shared C. Soitu· 2 shared G. Forte· 2 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersBiophysics

D. Marenduzzo

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy

F. Nebuloni, Q. Do, P. R. Cook, E. Walsh, R. Wade-Martins

This paper introduces a microfluidic platform to model human neuronal circuits and axotomy, enabling the study of connectivity and regeneration in vitro.

bioRxiv · Oct 14, 2023Bioengineering

Cluster size determines internal structure of transcription factories in human cells

M. Semeraro, G. Negro, G. Forte, A. Suma, G. Gonnella, P. R. Cook, D. Marenduzzo

This study develops a chromatin polymer model to show that cluster size determines whether transcription factories are specialised or mixed, reconciling conflicting experimental results.

bioRxiv · Jan 16, 2023Biophysics

Bridging-mediated compaction of mitotic chromosomes

G. Forte, L. Boteva, N. Gilbert, P. R. Cook, D. Marenduzzo

This paper uses simulations to show bridging factors create mitotic-like chromosome structures without energy input, matching experimental observations.

bioRxiv · Sep 27, 2022Biophysics

Reconfigurable microfluidic circuits for isolating and retrieving cells of interest

C. Deroy, J. H. R. Wheeler, A. N. Rumianek, P. R. Cook, W. M. Durham, K. R. Foster, E. J. Walsh

This paper introduces a microfluidic method to isolate and retrieve cells of interest by using fluid walls to access specific phenotypes in real-time.

bioRxiv · Dec 23, 2021Bioengineering

Complex small-world regulatory networks emerge from the 3D organisation of the human genome

C. A. Brackley, N. Gilbert, D. Michieletto, A. Papantonis, M. C. F. Pereira, P. R. Cook, D. Marenduzzo

This study shows that 3D genome organization leads to complex small-world regulatory networks and stochastic transcription, explaining how GWAS results align with overexpression experiments.

Nature Communications · Oct 1, 2021Peer-reviewedBiophysics

Creating wounds in cell monolayers using micro-jets

C. Soitu, M. Panea, A. A. Castrejon-Pita, P. R. Cook, E. Walsh

This paper introduces a contactless method to create customizable 2D wounds in cell monolayers using micro-jets and a biocompatible fluorocarbon, enabling automation and multiplexing in standard Petri dishes.

bioRxiv · Jan 7, 2021Bioengineering

Jet-printing microfluidic devices on demand

C. Soitu, N. Stovall-Kurtz, C. Deroy, A. Castrejon-Pita, P. R. Cook, E. Walsh

The paper describes a method to fabricate microfluidic circuits on Petri dishes using liquid fluorocarbon to create stable fluid walls for cell cloning and continuous cell feeding.

bioRxiv · May 31, 2020Bioengineering

Shaping Epigenetic Memory via Genomic Bookmarking

D. Michieletto, M. Chiang, D. Coli, A. Papantonis, E. Orlandini, P. R. Cook, D. Marenduzzo

This paper introduces a biophysical model of genomic bookmarking to explain how epigenetic domains are maintained and modified through histone marks and protein interactions in Drosophila.

bioRxiv · Nov 20, 2017Biophysics

Non-equilibrium chromosome looping via molecular slip-links

C. A. Brackley, J. Johnson, D. Michieletto, A. N. Morozov, M. Nicodemi, P. R. Cook, D. Marenduzzo

This paper introduces a model for chromatin loop formation through diffusive sliding of molecular slip-links, showing it can explain experimental biases without requiring motor activity.

bioRxiv · Dec 21, 2016Biophysics