Transient Commensal Clonal Interactions Can Drive Tumor Metastasis
S. Naffar-Abu Amara, H. J. Kuiken, L. M. Selfors, T. Butler, M. L. Leung, C. T. Leung, E. P. Kuhn, T. R. Kolarova, C. Hage, K. Ganesh, R. Foster, B. R. Rueda, A. Aktipis, P. T. Spellman, T. Ince, , J. S. S. Brugge
The paper shows that transient interactions between non-tumorigenic and tumorigenic clones can drive metastasis through amphiregulin-mediated mesothelial clearance.
bioRxiv · Jan 16, 2020 · PreprintCancer Biology