Author

K. Ganesh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Research Focus:clustering· 3 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Cercek· 2 shared A. Luthra· 2 shared E. Pappou· 2 shared J. Garcia-Aguilar· 2 shared J. Shia· 2 shared M. R. Weiser· 2 shared A. Aktipis· 1 shared A. Barlas· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Cercek

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Inferring cancer type-specific patterns of metastatic spread using Metient

D. Koyyalagunta, K. Ganesh, Q. Morris

Metient infers cancer type-specific metastatic spread patterns using gradient-based optimization, revealing new insights into metastasis mechanisms and treatment strategies.

bioRxiv · Jul 9, 2024Cancer Biology

Progressive plasticity during colorectal cancer metastasis

A. Moorman, F. Cambuli, E. Benitez, Q. Jiang, Y. Xie, A. Mahmoud, M. Lumish, S. Hartner, S. Balkaran, J. Bermeo, S. Asawa, C. Firat, A. Saxena, A. Luthra, V. Sgambati, , K. Ganesh

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

bioRxiv · Aug 18, 2023Cancer Biology

Chemotherapy Signatures Map Evolution of Therapy-Related Myeloid Neoplasms

B. T. Diamond, B. Ziccheddu, K. H. Maclachlan, J. Taylor, E. Boyle, J. Arrango Ossa, J. T. Jahn, M. Affer, T. M. Totiger, D. G. Coffey, J. Watts, S. X. Lu, N. Bolli, K. Bolton, J. H. Park, , F. Maura

The paper reconstructs the evolutionary history of therapy-related myeloid neoplasms using chemotherapy-associated mutational signatures and identifies distinct mutational patterns linked to different chemotherapies.

bioRxiv · Apr 26, 2022 · PreprintCancer Biology

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

B. Nguyen, C. Fong, A. Luthra, S. A. Smith, R. G. DiNatale, S. Nandakumar, H. Walch, W. K. Chatila, R. Madupuri, R. Kundra, C. M. Bielski, B. Mastrogiacomo, A. Boire, S. Chandarlapaty, K. Ganesh, , Varghes

The paper analyzes genomic data from 25,000 patients to identify associations between genomic alterations and metastatic patterns across 50 tumor types, finding chromosomal instability correlates with metastatic burden in some cancers.

bioRxiv · Jun 28, 2021Cancer Biology

Transient Commensal Clonal Interactions Can Drive Tumor Metastasis

S. Naffar-Abu Amara, H. J. Kuiken, L. M. Selfors, T. Butler, M. L. Leung, C. T. Leung, E. P. Kuhn, T. R. Kolarova, C. Hage, K. Ganesh, R. Foster, B. R. Rueda, A. Aktipis, P. T. Spellman, T. Ince, , J. S. S. Brugge

The paper shows that transient interactions between non-tumorigenic and tumorigenic clones can drive metastasis through amphiregulin-mediated mesothelial clearance.

bioRxiv · Jan 16, 2020 · PreprintCancer Biology

A rectal cancer model establishes a platform to study individual responses to chemoradiation

K. Ganesh, C. Wu, K. P. O'Rourke, M. Adileh, B. C. Szeglin, I. Wasserman, M. R. Marco, M. Shady, Y. Zheng, W. R. Karthaus, H. H. Won, S.-H. Choi, R. A. Pelossof, A. Barlas, E. Pappou, , J. J. Smith

This study develops a rectal cancer organoid model that mimics patient tumor responses to chemoradiation and metastasis in mice.

bioRxiv · May 22, 2019 · PreprintCancer Biology