E. Avezov

Luminal transport rates through intact endoplasmic reticulum limit the magnitude of localized Ca2+ signals

The paper shows that ER shape affects Ca2+ release efficiency through transport limitations and buffer protein mobility.

Fluid mechanics of luminal transport in actively contracting endoplasmic reticulum

The paper develops a computational model to study luminal transport in actively contracting ER tubules and finds that only peripheral sheet contractions can reproduce experimental transport velocities.

ERnet: a tool for the semantic segmentation and quantitative analysis of endoplasmic reticulum topology for video-rate super-resolution imaging

ERnet quantifies ER topology dynamics using video-rate super-resolution imaging and semantic segmentation, enabling analysis of ER morphology changes in response to genetic or metabolic perturbations.

Intracellular Aβ42 aggregation leads to cellular thermogenesis

This paper shows that Aβ42 aggregation in live cells increases intracellular temperature, which can be mitigated by aggregation inhibitors and is independent of mitochondrial damage.

High-throughput super-resolution single particle trajectory analysis reconstructs organelle dynamics and membrane re-organization

This paper introduces a computational method to analyze high-throughput super-resolution single-particle trajectories, enabling reconstruction of organelle dynamics and membrane reorganization.

Endoplasmic Reticulum morphological regulation by RTN4/NOGO modulates neuronal regeneration by slowing luminal transport

The paper shows RTN4/NOGO regulates ER morphology, which modulates luminal transport and Ca2+ delivery, affecting axonogenesis in neurons.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

The structure and global distribution of the endoplasmic reticulum network is actively regulated by lysosomes

This study shows lysosomes actively regulate ER remodeling by repositioning, affecting ER tubule distribution and morphology in response to metabolic changes.

TriPer, an optical probe tuned to the endoplasmic reticulum, tracks H2O2 consumption by glutathione

The paper develops TriPer, an optical probe that detects H2O2 in the ER, revealing glutathione's role in H2O2 turnover during protein folding.