Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation
R. M. Myers, F. Izzo, S. Kottapalli, T. Prieto, A. Dunbar, R. L. Bowman, E. P. Mimitou, M. Stahl, S. El Ghaity-Beckley, J. Arandela, R. Raviram, S. Ganesan, L. Mekerishvili, R. Hoffman, R. Chaligne, , D. A. Landau
This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.
bioRxiv · May 11, 2022 · PreprintCancer Biology