Author

D. A. Landau

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 6 Organism:human· 6 Research Focus:differential expression· 5 Approach:experimental assay· 5 Assay:scRNA-seq· 5 Approach:deep learning· 4 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

R. Chaligne· 4 shared F. Izzo· 3 shared O. Abdel-Wahab· 3 shared P. Smibert· 3 shared R. Hoffman· 3 shared S. Ganesan· 3 shared A. D. Swett· 2 shared A. Dunbar· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

R. Chaligne

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Defining ancestry, heritability and plasticity of cellular phenotypes in somatic evolution

J. S. Schiffman, A. R. D'Avino, T. Prieto, Y. Pang, Y. Fan, S. Rajagopalan, C. Potenski, T. Hara, M. L. Suva, C. Gawad, D. A. Landau

The paper introduces PATH, a framework to quantify heritability and plasticity of cellular phenotypes in somatic evolution using single-cell data from mouse and human samples.

Nature Genetics · Sep 24, 2024Peer-reviewedEvolutionary Biology

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

N. Ben-Chetrit, X. Niu, J. Sotelo, A. D. Swett, V. K. Rajasekhar, M. S. Jiao, C. M. Stewart, P. Bhardwaj, S. Kottapalli, S. Ganesan, P.-L. Loyher, C. Potenski, A. Hannuna, K. A. Brown, N. M. Iyengar, , D. A. Landau

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

bioRxiv · Oct 24, 2023 · PreprintCancer Biology

Type 1 interferon perturbates clonal competition by reshaping human blood development

C. Lama, D. Isakov, S. Rosenberg, M. Quijada-Alamo, M. S. Saurty-Seerunghen, S. Moein, T.-A. Abera, O. Sakaguchi, M. Totwani, G. Freed, C.-L. Poon, N. Parghi, A. Kubas-Meyer, A. X. Xie, M. Omar, , A. S. Nam

The paper investigates how type 1 interferon affects clonal competition in human blood development by altering HSC differentiation states and clonal fitness.

bioRxiv · Sep 28, 2022Cancer Biology

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

F. Gaiti, P. Chamely, A. G. Hawkins, M. Cortes-Lopez, A. D. Swett, S. Ganesan, T. H. Mouhieddine, X. Dai, L. Kluegel, C. Chen, K. Batta, J. Beaulaurier, A. W. Drong, S. Hickey, N. Dusaj, , D. A. Landau

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

bioRxiv · Jun 8, 2022 · PreprintCancer Biology

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

A. Dunbar, R. L. Bowman, Y. Park, F. Izzo, R. M. Myers, A. Karzai, W. Jun Kim, I. Fernandez Maestre, M. R. Waarts, A. Nazir, W. Xiao, M. Brodsky, M. Farina, L. Cai, S. F. Cai, , R. L. Levine

This study shows that reversible activation of Jak2V617F in a mouse model demonstrates its essential role in myeloproliferative neoplasms and highlights the therapeutic potential of mutant-specific JAK2 inhibition.

bioRxiv · May 18, 2022 · PreprintCancer Biology

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation

R. M. Myers, F. Izzo, S. Kottapalli, T. Prieto, A. Dunbar, R. L. Bowman, E. P. Mimitou, M. Stahl, S. El Ghaity-Beckley, J. Arandela, R. Raviram, S. Ganesan, L. Mekerishvili, R. Hoffman, R. Chaligne, , D. A. Landau

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

bioRxiv · May 11, 2022 · PreprintCancer Biology

High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations

A. S. Nam, K.-T. Kim, R. Chaligne, F. Izzo, C. Ang, G. Abu-Zeinah, N. D. Omans, A. Pastore, J. Taylor, A. Alonso, M. Mariani, J. R. Cubillos-Ruiz, W. Tam, R. Hoffman, J. M. Scandura, , D. A. Landau

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.

bioRxiv · Oct 16, 2018Cancer Biology