S-nitrosoglutathione reductase deficiency causes aberrant placental S-nitrosylation and preeclampsia.
S. Kulandavelu, R. A. Dulce, C. I. Murray, M. A. Bellio, J. Fritsch, R. Kanashiro-Takeuchi, H. Arora, E. Paulino, D. Soetkamp, W. Balkan, J. E. Van Eyk, J. M. Hare
This study shows that GSNOR deficiency in mice causes preeclampsia through dysregulated placental S-nitrosylation, which can be reversed by ascorbate.
bioRxiv · Jul 1, 2020Physiology