H. Arora

Adult-type diffuse gliomas share recurring cell states driven by a common astrocyte-like glioma stem cell population

This study identifies recurring cell states across adult-type diffuse gliomas and reveals a shared astrocyte-like glioma stem cell population driving intratumoural heterogeneity.

Synthetic Genitourinary Image Synthesis via Generative Adversarial Networks: Enhancing AI Diagnostic Precision

This paper generates synthetic genitourinary images using GANs to improve diagnostic model performance, showing high quality and pathologist approval.

Protein Translation Dysregulation and Immune Cell Evasion Define Metastatic Clones in HPV-related Cancer of the Oropharynx

This study identifies mechanisms of immune evasion and metastasis in HPV-related oropharyngeal cancer using single-cell and spatial genomic data, showing dysregulated protein translation and immune pathway suppression in metastatic clones.

Synthetic Histology Images for Training AI Models: A Novel Approach to Improve Prostate Cancer Diagnosis

This paper generates synthetic histology images using GANs to train an AI model for prostate cancer grading, showing improved performance compared to models trained on real data.

An ATP-Binding Cassette Transporter Gene Links Innate and Adaptive Immune Responses

This study identifies ABCF1 as a critical link between innate and adaptive immunity by regulating OAS1 and RNaseL activity, influencing antiviral responses to SARS-CoV-2 and VSV.

Phagocytosis in macrophages is regulated by the ATP-binding cassette family gene ABCF1

This study identifies ABCF1 as a regulator of phagocytosis in macrophages through its role in signaling pathways involving Src family kinases and SYK.

S-nitrosoglutathione Inhibits the Growth of Androgen-Receptor Dependent and Castration Resistant Prostate Cancer by Modulating FOXM1 Signaling

This study identifies GSNO as a nitric oxide donor that inhibits CRPC growth by targeting FOXM1, regardless of AR status.

Nitric oxide S-nitrosylates CSF1R to augment the action 1 of CSF1R inhibition against castration resistant prostate cancer

This study shows that nitric oxide enhances the effectiveness of CSF1R inhibition in castration-resistant prostate cancer by promoting S-nitrosylation of CSF1R, improving tumor suppression and immune response.

One Scaffold - Different Organelles Sensors: pH-Activable Fluorescent Probes for Targeting Live Primary Microglial Cell Organelles

The paper designs pH-activable fluorescent probes with a common scaffold for targeting different organelles in live primary microglial cells, showing differential fluorescence and pKa based on functional group changes.

S-nitrosoglutathione reductase deficiency causes aberrant placental S-nitrosylation and preeclampsia.

This study shows that GSNOR deficiency in mice causes preeclampsia through dysregulated placental S-nitrosylation, which can be reversed by ascorbate.

BjuWRR1, a CC-NB-LRR gene identified in Brassica juncea, confers resistance to white rust caused by Albugo candida

The paper identifies and validates BjuWRR1, a CC-NB-LRR gene in Brassica juncea, as a resistance gene against white rust caused by Albugo candida through genetic transformation.