Author

J. E. Van Eyk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Physiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

S. Kreimer· 3 shared A. Haghani· 2 shared A. Momenzadeh· 2 shared E. Damoc· 2 shared K. Raedschelders· 2 shared A. Binek· 1 shared A. Hakimi· 1 shared A. Hauspurg· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

S. Kreimer

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Author profile →

7 papers

Recent·Most cited

Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discovery

Q. Fu, M. Vegesna, N. Sundararaman, E. Damoc, T. N. Arrey, A. Pashkova, E. Mengesha, P. Debbas, S. Joung, D. Li, S. Cheng, J. Braun, D. P. B. McGovern, C. Murray, Y. Xuan, J. E. Van Eyk

This paper introduces TEAQ, a software tool that selects clinical-grade biomarker candidates from DIA-MS data by evaluating protein quantification metrics in a discovery cohort.

bioRxiv · Mar 20, 2024 · PreprintBiochemistry

Mechanical loading reveals an intrinsic cardiomyocyte stiffness contribution to diastolic dysfunction in murine cardiometabolic disease

J. V. Janssens, A. J. A. Raaijmakers, P. Koutsifeli, K. L. Weeks, J. R. Bell, J. E. Van Eyk, C. L. Curl, K. M. Mellor, L. M. D. Delbridge

This study shows that cardiomyocyte stiffness contributes to diastolic dysfunction in cardiometabolic disease, identified through in vitro mechanical testing of isolated cardiomyocytes from mice with diet-induced disease.

bioRxiv · Feb 21, 2024Physiology

Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics

T. Huang, J. Wang, A. Stukalov, M. K. R. Donovan, S. Ferdosi, L. Williamson, S. Just, G. Castro, L. S. Cantrell, E. Elgierari, R. W. Benz, Y. Huang, K. Motamedchaboki, A. Hakimi, T. Arrey, , D. Hornburg

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

bioRxiv · Aug 28, 2023 · PreprintBiochemistry

Complete Workflow for High Throughput Human Single Skeletal Muscle Fiber Proteomics

A. Momenzadeh, Y. Jiang, S. Kreimer, L. E. Teigen, C. S. Zepeda, A. Haghani, M. Mastali, Y. Song, A. Hutton, S. J. Parker, J. E. Van Eyk, C. W. Sundberg, J. G. Meyer

This paper introduces a high-throughput single skeletal muscle fiber proteomics method, achieving faster analysis with sufficient proteome depth compared to existing methods.

bioRxiv · Feb 23, 2023Biochemistry

Parallelization with Dual-Trap Single-Column Configuration Maximizes Throughput of Proteomic Analysis

S. Kreimer, A. Haghani, A. Binek, A. Hauspurg, S. Seyedmohammad, A. Rivas, A. Momenzadeh, J. Meyer, K. Raedschelders, J. E. Van Eyk

This paper introduces a dual-trap single-column configuration to improve proteomic analysis throughput by parallelizing column cleaning and sample loading, achieving high instrument utilization and reproducible quantification.

bioRxiv · Jun 2, 2022Biochemistry

A discovery-based proteomics approach identifies protein disulfide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes

F. Syed, D. Singhal, K. Raedschelders, P. Krishnan, R. N. Bone, M. R. McLaughlin, J. E. Van Eyk, R. G. Mirmira, M.-L. Yang, M. J. Mamula, H. Wu, X. Liu, C. Evans-Molina

The paper identifies PDIA1 as a biomarker of β cell stress in type 1 diabetes using proteomics and validation in mouse models and human samples.

bioRxiv · Dec 22, 2021 · PreprintPhysiology

S-nitrosoglutathione reductase deficiency causes aberrant placental S-nitrosylation and preeclampsia.

S. Kulandavelu, R. A. Dulce, C. I. Murray, M. A. Bellio, J. Fritsch, R. Kanashiro-Takeuchi, H. Arora, E. Paulino, D. Soetkamp, W. Balkan, J. E. Van Eyk, J. M. Hare

This study shows that GSNOR deficiency in mice causes preeclampsia through dysregulated placental S-nitrosylation, which can be reversed by ascorbate.

bioRxiv · Jul 1, 2020Physiology