Author

R. A. Dulce

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

J. M. Hare· 5 shared W. Balkan· 4 shared L. M. Takeuchi· 3 shared A. V. Schally· 2 shared H. ARORA· 2 shared R. Cai· 2 shared S. Kulandavelu· 2 shared A. C. Rieger· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersPhysiology

J. M. Hare

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Author profile →

5 papers

Recent·Most cited

Efficacy of a Growth Hormone-Releasing Hormone Agonist in a Murine Model of Cardiometabolic Heart Failure with Preserved Ejection Fraction

R. M. K. Takeuchi, L. M. Takeuchi, R. A. Dulce, K. Kazmierczak, W. Balkan, R. Cai, W. Sha, A. V. Schally, J. M. Hare

This study tests the efficacy of GHRH agonist MR-356 in a murine model of cardiometabolic HFpEF, showing improvements in cardiac function and metabolic inflammation markers.

bioRxiv · Sep 18, 2022Physiology

Nitric oxide S-nitrosylates CSF1R to augment the action 1 of CSF1R inhibition against castration resistant prostate cancer

M. Kuchakulla, F. FIRDAUS, R. QURESHI, Y. SONI, D. Van Booven, K. SHAH, R. A. Dulce, T. Masterson, O. J. Rosete, J. M. Hare, R. RAMASAMY, H. ARORA

This study shows that nitric oxide enhances the effectiveness of CSF1R inhibition in castration-resistant prostate cancer by promoting S-nitrosylation of CSF1R, improving tumor suppression and immune response.

bioRxiv · Jun 9, 2022 · PreprintCancer Biology

S-nitrosoglutathione reductase deficiency causes aberrant placental S-nitrosylation and preeclampsia.

S. Kulandavelu, R. A. Dulce, C. I. Murray, M. A. Bellio, J. Fritsch, R. Kanashiro-Takeuchi, H. Arora, E. Paulino, D. Soetkamp, W. Balkan, J. E. Van Eyk, J. M. Hare

This study shows that GSNOR deficiency in mice causes preeclampsia through dysregulated placental S-nitrosylation, which can be reversed by ascorbate.

bioRxiv · Jul 1, 2020Physiology

Effectiveness of Growth Hormone Releasing Hormone Agonists (GHRH A) in Chronic Kidney Disease Induced Heart Failure with Preserved Ejection Fraction

A. C. Rieger, L. L. Bagno, A. Salerno, V. Florea, J. Rodriguez, M. Rosado, D. Turner, L. M. Takeuchi, R. A. Dulce, W. Balkan, I. H. Schulman, A. Schally, J. M. Hare

This study tests GHRH-A treatment in a CKD-induced HFpEF pig model, finding improved diastolic function after 6 weeks of treatment.

bioRxiv · May 30, 2020 · PreprintPhysiology

Synthetic Agonist of Growth Hormone-Releasing Hormone as Novel Treatment for Heart Failure with Preserved Ejection Fraction

R. A. Dulce, R. M. Kanashiro-Takeuchi, L. M. Takeuchi, A. G. Salerno, S. Kulandavelu, W. Balkan, M. S. Zuttion, R. Cai, A. V. Schally, J. M. Hare

This paper tests a synthetic GHRH agonist, MR-356, in a mouse model of HFpEF, showing it prevents and reverses cardiac remodeling and dysfunction.

bioRxiv · Feb 28, 2020 · PreprintCell Biology