Mitochondrial Redox Adaptations Enable Aspartate Synthesis in SDH-deficient Cells
M. L. Hart, E. Quon, A.-L. B. G. Vigil, I. A. Engstrom, O. J. Newsom, K. Davidsen, P. Hoellerbauer, S. M. Carlisle, L. B. Sullivan
This study shows that SDH-deficient cells can restore aspartate synthesis and proliferation by inhibiting complex I, driven by mitochondrial redox changes.
bioRxiv · Mar 14, 2022Biochemistry