Author

L. B. Sullivan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 5 Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:metabolism & bioenergetics· 2

Frequent Co-Authors

K. Davidsen· 3 shared A.-L. B. G. Vigil· 2 shared Z. Li· 2 shared A. Aggarwal· 1 shared A. Ali· 1 shared A. Cardinale· 1 shared A. G. Paulovich· 1 shared A. L. H. Webster· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersBiochemistry

K. Davidsen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A robust method for measuring aminoacylation through tRNA-Seq

K. Davidsen, L. B. Sullivan

This paper introduces an optimized tRNA-Seq method for precise and accurate tRNA charge measurement, scalable to hundreds of samples with accompanying software.

bioRxiv · Jul 31, 2023Biochemistry

A Compound that Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

T. Uo, K. K. Ojo, C. C. Sprenger, K. S. Epilepsia, B. G. K. Perera, M. Damodarasamy, S. Sun, S. Kim, H. H. Hogan, M. A. Hulverson, R. Choi, G. R. Whitman, L. K. Barrett, S. A. Michaels, L. H. Xu, , S. R. Plymate

This paper evaluates a novel antiglycolytic compound, BKIDC-1553, showing selective growth inhibition of prostate cancer cells and safety for clinical trials.

bioRxiv · Jul 1, 2023Cancer Biology

An engineered biosensor enables dynamic aspartate measurements in living cells

K. Davidsen, J. S. Marvin, A. Aggarwal, T. A. Brown, L. B. Sullivan

This paper develops a GFP-based biosensor to dynamically measure aspartate levels in living cells, showing it correlates with mass spectrometry measurements and detects temporal changes in aspartate concentration.

bioRxiv · Jun 27, 2023Biochemistry

Damage-induced pyroptosis drives endogenous thymic regeneration viainduction of Foxn1 by purinergic receptor activation

S. Kinsella, C. A. Evandy, K. Cooper, A. Cardinale, L. Iovino, P. deRoos, K. S. Hopwo, C. W. Smith, D. W. Granadier, L. B. Sullivan, E. Velardi, J. Dudakov

The paper identifies that damage-induced pyroptosis of thymocytes, mediated by purinergic receptor activation and Foxn1 upregulation, drives thymic regeneration after acute injury.

bioRxiv · Jan 19, 2023 · PreprintImmunology

Fanconi anemia-isogenic head and neck cancer cell line pairs - a basic and translational science resource

H. T. Nguyen, W. Tang, A. L. H. Webster, J. R. Whiteaker, C. M. Chandler, R. Errazquin, L. B. Sullivan, E. Jonlin, E. E. Hoskins, E. Y. Chen, M. Fritzke, A. G. Paulovich, S. I. Wells, K. Roohollahi, J. Dorsman, , R. J. Monnat

The paper develops isogenic head and neck cancer cell line pairs to study Fanconi anemia-associated cancers and their treatment.

bioRxiv · Sep 11, 2022Cancer Biology

Mitochondrial Redox Adaptations Enable Aspartate Synthesis in SDH-deficient Cells

M. L. Hart, E. Quon, A.-L. B. G. Vigil, I. A. Engstrom, O. J. Newsom, K. Davidsen, P. Hoellerbauer, S. M. Carlisle, L. B. Sullivan

This study shows that SDH-deficient cells can restore aspartate synthesis and proliferation by inhibiting complex I, driven by mitochondrial redox changes.

bioRxiv · Mar 14, 2022Biochemistry

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

A. Luengo, Z. Li, D. Y. Gui, L. B. Sullivan, M. Zagorulya, B. T. Do, R. Ferriera, A. Naamati, A. Ali, C. A. Lewis, C. J. Thomas, S. Spranger, N. J. Matheson, M. G. Vander Heiden

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

bioRxiv · Jun 8, 2020Biochemistry

Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited

Z. Li, B. W. Ji, P. D. Dixit, E. C. Lien, K. Tchourine, A. M. Hosios, K. L. Abbott, A. M. Westermark, E. F. Gorodetsky, L. B. Sullivan, M. Vander Heiden, D. Vitkup

This study shows that cancer cells rely on environmental lipids for proliferation under conditions of limited electron acceptors, such as hypoxia or mitochondrial inhibition.

bioRxiv · Jun 8, 2020Cancer Biology