Author

P. Hoellerbauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:CRISPR screen· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:genetic perturbation / CRISPR· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

M. Kufeld· 5 shared P. PADDISON· 5 shared S. Arora· 5 shared H. Feldman· 3 shared A. Patel· 2 shared E. Girard· 2 shared J. Herman· 2 shared J. Olson· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersCancer Biology

M. Kufeld

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Functional genomic analysis of adult and pediatric brain tumor isolates

P. Hoellerbauer, M. Biery, S. Arora, Y. Rao, E. Girard, K. Mitchell, P. Dighe, M. Kufeld, D. Kuppers, J. Herman, E. Holland, L. Soroceanu, N. Vitanza, J. Olson, J. Pritchard, P. PADDISON

This study identifies shared and unique gene dependencies between adult and pediatric brain tumor isolates using CRISPR screens and machine learning models.

bioRxiv · Jan 5, 2023 · PreprintCancer Biology

FBXO42 activity is required to prevent mitotic arrest, spindle assembly checkpoint activation, and lethality in glioblastoma and other cancers

P. Hoellerbauer, M. Kufeld, S. Arora, E. Girard, J. Herman, J. Olson, P. PADDISON

This study identifies FBXO42 as essential for preventing mitotic arrest and cell death in glioblastoma and other cancers by suppressing chromosome-microtubule dynamics disruption.

bioRxiv · Nov 29, 2022 · PreprintCancer Biology

KAT5 regulates neurodevelopmental states associated with G0-like populations in glioblastoma

A. Mihalas, S. Arora, S. O'Connor, H. Feldman, C. E. Cucinotta, K. Mitchell, J. Bassett, D. Kim, K. Jin, P. Hoellerbauer, J. Delegard, M. Ling, W. Jenkins, M. Kufeld, P. Corrin, , P. PADDISON

This study identifies KAT5 as a regulator of G0-like states in glioblastoma, showing its role in suppressing non-dividing subpopulations and associating with worse patient outcomes.

bioRxiv · Mar 17, 2022Cancer Biology

Mitochondrial Redox Adaptations Enable Aspartate Synthesis in SDH-deficient Cells

M. L. Hart, E. Quon, A.-L. B. G. Vigil, I. A. Engstrom, O. J. Newsom, K. Davidsen, P. Hoellerbauer, S. M. Carlisle, L. B. Sullivan

This study shows that SDH-deficient cells can restore aspartate synthesis and proliferation by inhibiting complex I, driven by mitochondrial redox changes.

bioRxiv · Mar 14, 2022Biochemistry

A simple and highly efficient method for multi-allelic CRISPR-Cas9 editing in primary cell cultures

P. Hoellerbauer, M. Kufeld, S. Arora, H.-J. Wu, H. Feldman, P. PADDISON

This paper introduces an optimized CRISPR-Cas9 method for efficient gene knockout and genomic deletion in primary cells, achieving >90% indel formation in 3 days.

bioRxiv · Jul 1, 2020Cell Biology

Neural G0: a quiescent-like state found in neuroepithelial-derived cells and glioma

H. Feldman, C. Toledo, S. Arora, P. Hoellerbauer, P. Corrin, L. Carter, M. Kufeld, H. Bolouri, R. Basom, J. Delrow, J. McFaline-Figueroa, C. Trapnell, S. Pollard, A. Patel, C. Plaisier, P. Paddison

The paper identifies a quiescent-like state, Neural G0, in human neural stem cells and gliomas using scRNA-seq, linking it to tumor aggressiveness and survival.

bioRxiv · Feb 16, 2020 · PreprintCell Biology