BiochemistrybioRxiv
Mitochondrial Redox Adaptations Enable Aspartate Synthesis in SDH-deficient Cells
M. L. Hart, E. Quon, A.-L. B. G. Vigil…·L. B. Sullivan
This study shows that SDH-deficient cells can restore aspartate synthesis and proliferation by inhibiting complex I, driven by mitochondrial redox changes.
DOI 10.7554/elife.78654