S. V. Nielsen

Its a Trap?! Escape from an ancient, ancestral sex chromosome system and implication of Foxl2 as the putative primary sex determining gene in a lizard (Anguimorpha; Shinisauridae)

The paper identifies a novel ZW sex chromosome system on LG3 in Shinisaurus, with Foxl2 as a candidate primary sex determining gene.

Structural basis for kinase inhibition in the tripartite E. coli HipBST toxin-antitoxin system

The paper investigates the structural basis of kinase inhibition in the E. coli HipBST toxin-antitoxin system, showing how HipS inhibits HipT through active site insertion and how phosphorylation affects complex flexibility.

Disease-linked mutations trigger exposure of a protein quality control degron in the DHFR protein

The paper identifies two PQC degrons in DHFR that become exposed in disease-linked missense variants, leading to proteasomal degradation.

The first chromosome-level gecko genome reveals dynamic sex chromosomes in Neotropical leaf-litter geckos (Sphaerodactylidae: Sphaerodactylus)

The paper presents the first chromosome-level gecko genome and identifies multiple sex chromosome transitions in Sphaerodactylus geckos.

Rampant tooth loss across 200 million years of frog evolution

This study analyzes tooth loss across 200 million years of frog evolution, finding repeated losses in frogs linked to diet and jaw morphology but not body size.

Understanding the origins of loss of protein function by analyzing the effects of thousands of variants on activity and abundance

The paper analyzes variant effects on protein activity and abundance in NUDT15 and PTEN, finding that a third of variants cause loss of function and half of these also reduce abundance.

Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

The paper identifies structural destabilization and degradation of MLH1 variants in Lynch syndrome, linking reduced cellular levels to loss-of-function and suggesting stability predictions for diagnostic use.

Transcriptomic data support a nocturnal bottleneck in the ancestor to gecko lizards

The paper uses transcriptomic data to identify a nocturnal bottleneck in the ancestor of gecko lizards, suggesting evolutionary changes in photoreceptor cells and gene expression.