Author

E. R. O'Brien

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Shi· 3 shared J. Deng· 3 shared Y.-X. Chen· 3 shared C. Diao· 2 shared J. Liu· 2 shared M. Rosin· 2 shared N. Maarouf· 2 shared V. Shrivastava· 2 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersPathology

C. Shi

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3 papers

Recent·Most cited

Heat Shock Protein 27 versus Estrogen Therapy for Post-Menopausal Atherosclerosis: Rethinking Mechanisms of Cholesterol Lowering

N. Maarouf, Y.-X. Chen, C. Shi, J. Deng, C. Diao, M. Rosin, V. Shrivastava, Z. Batulan, J. Liu, E. R. O'Brien

This study compares the effects of HSP25 vaccination and estrogen therapy on atherogenesis in post-menopausal mice, finding that both reduce plaque but through different mechanisms involving PCSK9 and LDLR.

bioRxiv · Jun 4, 2020Pathology

Heat Shock Protein 27 Immune Complex Altered Signaling and Transport (ICAST): Novel Mechanisms of Attenuating Inflammation

C. Shi, J. Deng, M. H. Chiu, Y.-X. Chen, E. R. O'Brien

The paper shows that HSP27 immune complexes reduce inflammation and cholesterol uptake by modulating TLR4 and scavenger receptors in macrophages.

bioRxiv · May 31, 2020Pathology

Heat Shock Protein 27 Immune Complex Upregulates LDLR Expression Thereby Reducing Plasma Cholesterol and Atherogenesis

Y.-X. Chen, C. Shi, J. Deng, C. Diao, N. Maarouf, M. Rosin, V. Shrivastava, A. Hu, S. Bharadwa, A. Adijiang, A. Ulke-Lemee, B. L. Gwilym, A. Hellmich, C. Malozzi, Z. Batulan, , E. R. O'Brien

The paper shows that HSP27 immune complexes increase LDLR expression, lowering plasma cholesterol and atherogenesis in ApoE-/- mice.

bioRxiv · May 21, 2020Pathology