Author

E. R. Scaletti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A.-S. Jemth· 2 shared P. Stenmark· 2 shared T. Helleday· 2 shared D. Kapsitidou· 1 shared E. J. Homan· 1 shared I. Almlof· 1 shared J. E. Unterlass· 1 shared K. S. Vallin· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBiochemistry

A.-S. Jemth

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2 papers

Recent·Most cited

Kinetic and structural characterization of human NUDIX hydrolase NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

E. R. Scaletti, J. E. Unterlass, I. Almlof, T. Koolmeister, K. S. Vallin, D. Kapsitidou, T. Helleday, P. Stenmark, A.-S. Jemth

This study identifies NUDT15 and NUDT18 as human enzymes that hydrolyze isoprene pyrophosphates, with NUDT18 showing the highest catalytic efficiency for geranyl pyrophosphate.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

A.-S. Jemth, E. R. Scaletti, E. J. Homan, P. Stenmark, T. Helleday, M. Michel

This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.

bioRxiv · Nov 16, 2021 · PreprintBiochemistry