Author

E. J. Homan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

A.-S. Jemth· 2 shared M. Michel· 2 shared T. Helleday· 2 shared A. Abraham· 1 shared C. B. Paulin· 1 shared C. Dirks· 1 shared C. Hall· 1 shared C. K. Lee· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

A.-S. Jemth

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Author profile →

4 papers

Recent·Most cited

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

S. M. Zhang, C. B. Paulin, M. Michel, P. Marttila, M. Yagüe-Capilla, H. C. Bwanika, H. Shu, R. Papagudi Vekatram, E. Wiita, A.-S. Jemth, I. Almlöf, O. Loseva, F. Ortis, C. Dirks, T. Koolmeister, , S. G. Rudd

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

bioRxiv · Jan 17, 2023 · PreprintBiochemistry

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

A.-S. Jemth, E. R. Scaletti, E. J. Homan, P. Stenmark, T. Helleday, M. Michel

This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.

bioRxiv · Nov 16, 2021 · PreprintBiochemistry

Protection of mice against experimental cryptococcosis by synthesized peptides delivered in glucan particles

C. Specht, E. J. Homan, C. K. Lee, Z. Mou, C. L. Gomez, M. M. Hester, A. Abraham, F. Rus, G. Ostroff, S. M. Levitz

The paper shows that glucan particle-based vaccines containing specific peptides from C. neoformans proteins can protect mice against cryptococcosis, with varying efficacy depending on the peptide and mouse strain.

bioRxiv · Nov 12, 2021Immunology

Brucella Peptide Cross-Reactive MHC I Presentation Activates SIINFEKL-Specific TCR Expressing T Cells

J. S. Harms, M. Khan, C. Hall, G. A. Splitter, E. J. Homan, R. D. Bremel, J. Smith

The paper shows that Brucella peptides can activate SIINFEKL-specific TCR-expressing T cells through cross-reactivity, suggesting immune evasion and potential autoimmunity.

bioRxiv · Apr 14, 2018Immunology