Author

T. Helleday

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cancer Biology· 3 Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Organism:human· 6 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

A.-S. Jemth· 4 shared C. Kalderen· 3 shared I. Almlof· 3 shared O. Mortusewicz· 3 shared P. Stenmark· 3 shared S. G. Rudd· 3 shared T. Koolmeister· 3 shared A. Egesten· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBiochemistry

A.-S. Jemth

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Kinetic and structural characterization of human NUDIX hydrolase NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

E. R. Scaletti, J. E. Unterlass, I. Almlof, T. Koolmeister, K. S. Vallin, D. Kapsitidou, T. Helleday, P. Stenmark, A.-S. Jemth

This study identifies NUDT15 and NUDT18 as human enzymes that hydrolyze isoprene pyrophosphates, with NUDT18 showing the highest catalytic efficiency for geranyl pyrophosphate.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

N. Zhang, L. Harbers, M. Simonetti, C. Diekmann, Q. Verron, E. Berrino, S. E. Bellomo, G. M. C. Longo, M. Ratz, N. Schultz, F. Tarish, P. Su, B. Han, W. Wang, S. Onorato, , N. Crosetto

bioRxiv · Nov 7, 2023Cancer Biology

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

S. M. Zhang, C. B. Paulin, M. Michel, P. Marttila, M. Yagüe-Capilla, H. C. Bwanika, H. Shu, R. Papagudi Vekatram, E. Wiita, A.-S. Jemth, I. Almlöf, O. Loseva, F. Ortis, C. Dirks, T. Koolmeister, , S. G. Rudd

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

bioRxiv · Jan 17, 2023 · PreprintBiochemistry

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

N. C. K. Valerie, K. Sanjiv, O. Mortusewicz, S. M. Zhang, S. Alam, M. J. Pires, H. Stigsdotter, A. Rasti, M.-F. Langelier, D. Rehling, A. Throup, M. Desroses, J. Onireti, P. Wakchaure, I. Almlof, , M. Altun

CeTEAM evaluates drug-target interactions and phenotypic responses using biosensors, revealing how drug binding affects cellular activities and metabolism.

bioRxiv · Sep 19, 2022Biochemistry

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

L. Tanner, J. Bergwik, R. K. Bhongir, L. Pan, C. Dong, C. Kalderen, T. Helleday, I. Boldogh, M. Adner, A. Egesten

This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.

bioRxiv · May 17, 2022 · PreprintPharmacology & Toxicology

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

A.-S. Jemth, E. R. Scaletti, E. J. Homan, P. Stenmark, T. Helleday, M. Michel

This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.

bioRxiv · Nov 16, 2021 · PreprintBiochemistry

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis

L. Tanner, A. B. Single, R. K. V. Bonghir, R. Oomen, O. Wallner, T. Helleday, C. Kalderen, A. Egesten

This study shows that the small-molecule OGG1 inhibitor TH5487 reduces fibrosis and inflammation in a mouse model of pulmonary fibrosis.

bioRxiv · Feb 27, 2021 · PreprintPharmacology & Toxicology

MTH1 inhibitor TH588 induces mitosis-dependent accumulation of genomic 8-oxodG and disturbs mitotic progression

S. G. Rudd, H. Gad, N. Amaral, A. Hagenkort, P. Groth, C. E. Strom, O. Mortusewicz, U. Warpman-Berglund, T. Helleday

The paper shows that MTH1 inhibitor TH588 causes genomic 8-oxodG accumulation during mitosis, leading to mitotic arrest and cytotoxicity.

bioRxiv · Sep 6, 2019Cancer Biology

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

bioRxiv · Sep 5, 2019 · PreprintCancer Biology