Author

E. Sammler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:flow cytometry· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

A. J. Howden· 1 shared A. Tasegian· 1 shared C. Klein· 1 shared D. Dikovskaya· 1 shared D. R. Alessi· 1 shared H. Staley· 1 shared K. McFarland· 1 shared K. Zenevicuite· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. J. Howden

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Author profile →

2 papers

Recent·Most cited

Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4

D. Dikovskaya, R. Pemberton, M. Taylor, A. Tasegian, K. Zenevicuite, E. Sammler, A. J. Howden, D. R. Alessi, M. Swamy

This study investigates how inflammation and IL-4 regulate LRRK2 expression and activity in immune cells, revealing cell-specific effects and the role of the LRRK2-R1441C mutation.

bioRxiv · Apr 29, 2024Immunology

The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

R. Wallings, K. McFarland, H. Staley, N. Neighbarger, S. Schaake, N. Brueggemann, S. Zittel, T. Usnich, C. Klein, E. Sammler, M. G. Tansey

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

bioRxiv · Oct 12, 2023Immunology