Author

M. G. Tansey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1

Frequent Co-Authors

H. Staley· 2 shared V. Joers· 2 shared A. G. Anderson· 1 shared A. Martin-Pena· 1 shared B. C. Murray· 1 shared B. M. Moore· 1 shared C. Achat-Mendes· 1 shared C. Klein· 1 shared

Activity by Year

2023-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

H. Staley

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Biochemical fractionation of human α-Synuclein in a Drosophila model of synucleinopathies

K. Imomnazarov, J. Lopez-Scarim, I. Bagheri, V. Joers, M. G. Tansey, A. Martin-Pena

The paper develops a protocol to assess human α-Synuclein solubility in Drosophila brains, distinguishing soluble and insoluble forms using detergent strength and sonication.

bioRxiv · Feb 5, 2024Biochemistry

The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

R. Wallings, K. McFarland, H. Staley, N. Neighbarger, S. Schaake, N. Brueggemann, S. Zittel, T. Usnich, C. Klein, E. Sammler, M. G. Tansey

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

bioRxiv · Oct 12, 2023Immunology

Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy

V. Joers, B. C. Murray, C. McLaughlin, D. Oliver, H. Staley, J. E. Coronado, C. Achat-Mendes, S. Golshani, S. D. Kelly, M. Goodson, D. Lee, F. P. Manfredsson, B. M. Moore, M. G. Tansey

This study shows that targeting CB2 with SMM-189 reduces alpha-synuclein aggregates and neuroinflammation in a rat model of Parkinson's disease.

bioRxiv · Aug 25, 2023Immunology

Loss of Progranulin Results in Increased Pan-Cathepsin Activity and Reduced LAMP1 Lysosomal Protein

A. G. Anderson, M. G. Tansey

This study shows that loss of PGRN increases pan-cathepsin activity and reduces LAMP1 expression in MEFs, suggesting a role for PGRN in lysosomal function and inflammation.

bioRxiv · Jul 15, 2023 · PreprintCell Biology