K. McFarland

The human genetic variant rs6190 unveils Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle.

This study identifies Foxc1 and Arid5a as novel pro-metabolic targets of the glucocorticoid receptor in muscle, using a human SNP rs6190 in mice and human datasets.

Glucocorticoid chrono-pharmacology unveils novel targets for the cardiomyocyte-specific GR-KLF15 axis in cardiac glucose metabolism

This study identifies the cardiomyocyte-specific GR-KLF15 axis as a circadian-regulated regulator of glucose metabolism, showing that timed glucocorticoid administration improves cardiac function in diabetic mice.

Glucocorticoid intermittence coordinates rescue of energy and mass in aging-related sarcopenia through the myocyte-autonomous PGC1alpha-Lipin1 transactivation

This study shows that intermittent glucocorticoid treatment rescues both energy and mass in aging-related sarcopenia via the PGC1alpha-Lipin1 pathway in muscle cells.

The R1441C-LRRK2 mutation induces myeloid immune cell exhaustion in an age- and sex-dependent manner

The R1441C-LRRK2 mutation leads to age-dependent immune cell exhaustion in macrophages, with sex-specific effects observed in mice and human patients.

Reproductive phenology of the eastern oyster, Crassostrea virginica (Gmelin, 1791), along a temperate estuarine salinity gradient

The study examines how salinity affects reproductive timing in eastern oysters across different ancestries and sites, finding delayed gametogenesis at low salinity in some seasons but not others.

Are bivalves susceptible to domestication selection? Using starvation tolerance to test for potential trait changes in eastern oyster larvae

This study tests if domestication selection affects starvation tolerance in eastern oyster larvae by comparing wild and selectively bred lines.