Author

A. J. Howden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:differential expression· 3 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

D. A. Cantrell· 3 shared J. M. Marchingo· 2 shared L. Spinelli· 2 shared L. V. Sinclair· 2 shared A. I. Lamond· 1 shared A. J. Brenes· 1 shared A. J. Brenes-Murillo· 1 shared A. N. Macintyre· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersImmunology

D. A. Cantrell

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Author profile →

6 papers

Recent·Most cited

Regulation of Leucine-Rich Repeat Kinase 2 by inflammation and IL-4

D. Dikovskaya, R. Pemberton, M. Taylor, A. Tasegian, K. Zenevicuite, E. Sammler, A. J. Howden, D. R. Alessi, M. Swamy

This study investigates how inflammation and IL-4 regulate LRRK2 expression and activity in immune cells, revealing cell-specific effects and the role of the LRRK2-R1441C mutation.

bioRxiv · Apr 29, 2024Immunology

Quantitative proteomics reveals tissue-specific, infection-induced and species-specific neutrophil protein signatures

G. Sollberger, A. J. Brenes, J. Warner, J. S. C. Arthur, A. J. Howden

The paper uses quantitative proteomics to identify tissue-specific, infection-induced, and species-specific neutrophil protein signatures in mice and humans.

bioRxiv · Sep 5, 2023 · PreprintImmunology

An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells

F. Salerno, A. J. Howden, L. S. Matheson, O. Gizlenci, M. Screen, H. Lingel, M. Brunner-Weinzierl, M. Turner

The paper integrates proteome and transcriptome data from mouse B cells to identify poised mRNAs and translational regulators involved in activation and antibody secretion.

bioRxiv · Dec 22, 2022Immunology

Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation

M. P. Damasio, J. M. Marchingo, L. Spinelli, D. A. Cantrell, A. J. Howden

This study uses mass spectrometry to identify ERK-regulated proteins in CD8+ T cells and reveals their role in transcriptional reprogramming and cytokine expression during activation.

bioRxiv · Aug 18, 2020Immunology

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

J. M. Marchingo, L. V. Sinclair, A. J. Howden, D. A. Cantrell

This study uses mass spectrometry to show Myc controls T cell proteomes and metabolic pathways by regulating amino acid transporters, which are critical for T cell activation and function.

bioRxiv · Nov 18, 2019Immunology

Antigen receptor control of methionine metabolism in T cells

L. V. Sinclair, A. J. Howden, A. J. Brenes-Murillo, L. Spinelli, J. L. Hukelmann, A. N. Macintyre, X. Liu, S. Thomson, P. M. Taylor, J. C. Rathmell, J. W. Locasale, A. I. Lamond, D. A. Cantrell

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

bioRxiv · Dec 18, 2018Immunology