Author

N. J. Francis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:chromatin & epigenetic regulation· 4 Organism:Drosophila· 4 Approach:experimental assay· 3 Assay:ChIP-seq· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Bihani· 1 shared A. Henrickson· 1 shared A. J. Mendiola· 1 shared B. Demeler· 1 shared C. A. Kim· 1 shared C. Alecki· 1 shared D. Grau· 1 shared D. Jeruzalmi· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Bihani

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A two-step mechanism for creating stable, condensed chromatin by the Polycomb complex PRC1

E. Seif, N. J. Francis

This study reveals a two-step mechanism by which the PRC1 complex creates stable chromatin condensates through phase separation and chromatin bridging.

bioRxiv · Dec 6, 2023 · PreprintBiochemistry

How a disordered linker in the Polycomb protein Polyhomeotic tunes phase separation and oligomerization

T. M. Gemeinhardt, R. M. Regy, T. M. Phan, N. Pal, J. Sharma, O. Senkovich, A. J. Mendiola, H. J. Ledterman, A. Henrickson, D. Lopes, U. Kapoor, A. Bihani, D. Sihou, Y. C. Kim, D. Jeruzalmi, , N. J. Francis

The paper investigates how a disordered linker in the Polyhomeotic protein influences phase separation and oligomerization in Drosophila and human cells through in vitro reconstitution and molecular dynamics simulations.

bioRxiv · Oct 26, 2023Biochemistry

Regulation of Polyhomeotic condensates by intrinsically disordered sequences that affect chromatin binding

I. Kapur, E. L. Boulier, N. J. Francis

This study identifies intrinsically disordered regions in the Polyhomeotic protein that regulate condensate formation and chromatin binding in Drosophila cells.

bioRxiv · Oct 4, 2021Biochemistry

RNA strand invasion activity of the Polycomb complex PRC2

C. Alecki, V. Chiwara, L. A. Sanz, D. Grau, O. Arias Perez, K.-J. Armache, F. Chedin, N. J. Francis

The paper identifies RNA strand invasion activity by PRC2 that drives R-loop formation at PREs, linking non-canonical nucleic acid structures to epigenetic regulation.

bioRxiv · May 15, 2019Biochemistry