Author

E. Sergienko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

C.-T. Ma· 2 shared A. A. Bobkov· 1 shared A. B. Pinkerton· 1 shared A. Khateb· 1 shared C. A. Hassig· 1 shared D. A. Scott· 1 shared D. Crawford· 1 shared E. Ruppin· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

C.-T. Ma

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural Basis for Substrate Binding, Catalysis and Inhibition of Breast Cancer Target Mitochondrial Creatine Kinase by Covalent Inhibitor via Cryo-EM

M. Demir, L. Koepping, Y. Li, L. Fujimoto, A. A. Bobkov, J. Zhao, T. Hitosugi, E. Sergienko

The paper investigates the structural and mechanistic features of mitochondrial creatine kinase (uMtCK) and evaluates the efficacy of a covalent inhibitor in breast cancer cells.

bioRxiv · Jun 18, 2024 · PreprintBiochemistry

Melanoma Addiction to GCDH is Mediated by NRF2 Tumor Suppressor Function

S. Verma, D. Crawford, A. Khateb, Y. Feng, E. Sergienko, G. Pathria, C.-T. Ma, S. H. Olson, D. A. Scott, R. Murad, E. Ruppin, M. Jackson, Z. A. Ronai

This study identifies melanoma addiction to GCDH, showing that GCDH controls NRF2 glutarylation, which limits apoptotic UPR signaling and tumor growth.

bioRxiv · Oct 22, 2021Cancer Biology

The serine-threonine kinase TAO3 promotes cancer invasion and tumor growth by facilitating trafficking of endosomes containing the invadopodia scaffold TKS5α

S. Iizuka, M. Quintavalle, J. Ceja Navarro, K. P. Gribbin, R. J. Ardecky, M. Abelman, C.-T. Ma, E. Sergienko, F.-Y. Zeng, I. Pass, G. Thomas, S. McWeeney, C. A. Hassig, A. B. Pinkerton, S. A. Courtneidge

bioRxiv · Feb 27, 2020Cancer Biology