Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity
X. Zhou, X. Zhu, C. Li, Y. Li, Z. Ye, V. M. Shapiro, J. A. Copland, T. Hitosugi, D. A. Bernlohr, J. Sun, H. Zeng
The paper shows that monounsaturated fatty acids (MUFA) are essential for B cell function and humoral immunity, with SCD-mediated MUFA production supporting early B cell development and germinal center formation.
bioRxiv · Apr 22, 2020Immunology