The purine nucleoside phosphorylase pnp-1 regulates epithelial cell resistance to infection in C. elegans
E. Tecle, C. B. Chhan, L. Franklin, R. S. Underwood, W. Hanna-Rose, E. R. Troemel
This paper identifies pnp-1 as a negative regulator of immune responses in C. elegans, showing that its loss increases resistance to both intracellular and extracellular pathogens.
bioRxiv · Feb 3, 2021Immunology