CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1
G. Yi, A. Mandoli, L. Jussen, E. Tijchon, G. Cordonnier, M. Hansen, B. Kim, L. N. Nguyen, P. Jansen, M. Vermeulen, E. van den Akker, J. Bond, J. H. A. Martens
This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.
bioRxiv · Oct 29, 2018Cancer Biology