M. Vermeulen

Characterization of DNA methylation reader proteins of Arabidopsis thaliana

The paper identifies and characterizes DNA methylation reader proteins in Arabidopsis thaliana, revealing context-specific binding preferences and functional roles.

Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia

The paper identifies HMX3 as a critical vulnerability in MECOM-negative KMT2A::MLLT3 AML, showing it promotes proliferation and blocks differentiation.

Enhancer plasticity in endometrial tumorigenesis demarcates non-coding somatic mutations and 3D-genome alterations boosting the oncogenic driver ESR1

The paper identifies enhancer plasticity and 3D-genome alterations in endometrial cancer that boost ESR1 expression through non-coding mutations and risk variants.

Single-cell transcriptomic analysis of NK cell dynamics in myeloma patients reveal persistent reduction of cytotoxic NK cells from diagnosis to relapse

Elevated glycolytic metabolism of monocytes limits the generation of HIF-1α-driven migratory dendritic cells in tuberculosis

This study shows that elevated glycolytic metabolism in monocytes during tuberculosis impairs their differentiation into migratory dendritic cells, limiting immune response.

An IL-1β driven neutrophil-stromal cell axis fosters a BAFF-rich microenvironment in multiple myeloma

The paper identifies a neutrophil-stromal cell feedback loop in multiple myeloma that promotes BAFF-rich inflammation, persisting after treatment and suggesting dual targeting strategies.

A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

This study identifies a novel antifolate, C1, that overcomes methotrexate resistance by targeting FPGS-deficient cells through DHFR inhibition.

Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells

This study identifies galectin-9 as essential for cytokine trafficking in dendritic cells by interacting with Vamp-3, preventing cytokine accumulation in the Golgi and promoting secretion.

THRONCAT: Efficient metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog

THRONCAT enables efficient, non-toxic labeling of newly synthesized proteins in various organisms using a threonine analog, demonstrating its utility in studying proteome dynamics and disease models.

Growth inhibition of Akkermansia muciniphila by a secreted pathobiont sialidase

The paper identifies a secreted sialidase from Allobaculum that inhibits Akkermansia muciniphila growth by altering its glycometabolic niche.

Arbovirus-vector protein interactomics identifies Loquacious as a co-factor for dengue virus replication in Aedes mosquitoes

The paper identifies Loquacious as a mosquito host factor essential for dengue and Zika virus replication, revealing its role in viral RNA replication independent of RNAi activity.

m6A reader Pho92 is recruited co-transcriptionally and couples translation efficacy to mRNA decay to promote meiotic fitness in yeast

Single-embryo phosphoproteomics reveals the importance of intrinsic disorder in cell cycle dynamics

The paper uses single-embryo phosphoproteomics to show that phosphorylation of intrinsically disordered proteins by cell cycle kinases drives switch-like mitotic reorganization.

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

This study shows that SARS-CoV-2 501Y.V2 pseudovirus escapes neutralization by South African convalescent plasma but not binding, suggesting potential for reinfection and reduced vaccine efficacy.

A CSB-PAF1C axis restores processive transcription elongation after DNA damage repair

This study identifies a PAF1C-dependent pathway that restores transcription elongation after DNA damage repair in human cells.

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

RNF43 truncating mutations mediate a tumour suppressor-to-oncogene switch to drive niche-independent self-renewal in cancer

This study identifies RNF43 truncating mutations that switch from tumor suppressor to oncogene, enabling niche-independent self-renewal in cancer and resistance to anti-Wnt therapy.

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.

The Tudor protein Veneno assembles the ping-pong amplification complex that produces viral piRNAs in Aedes mosquitoes

The paper identifies Veneno, a Tudor protein in Aedes aegypti, as essential for viral piRNA production via its role in assembling the ping-pong amplification complex with Ago3 and Piwi5.

Induction and suppression of NF-κB signalling by a DNA virus of Drosophila

This study investigates how a Drosophila DNA virus, Kallithea virus, interacts with the insect immune system, identifying gp83 as a Toll pathway inhibitor.