Author

L. N. Nguyen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Research Focus:differential expression· 2 Assay:metabolomics· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Cazenave-Gassiot· 3 shared D. T. Nguyen· 3 shared N. C. P. Leong· 3 shared T. Q. Nguyen· 3 shared H. T. T. Ha· 2 shared M. R. Wenk· 2 shared X. T. A. Nguyen· 2 shared A. Artati· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

A. Cazenave-Gassiot

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

MFSD7c functions as a transporter of choline at the blood-brain barrier

X. T. A. Nguyen, U. T. N. Le, H. T. T. Ha, T. Q. Nguyen, A. Artati, N. C. P. Leong, D. T. Nguyen, P. Y. Lim, A. V. Susanto, Q. Huang, L. Fam, N. L. Leong, I. Bonne, A. Lee, C. Gooch, , L. N. Nguyen

This study identifies MFSD7c as a choline transporter at the blood-brain barrier and links its dysfunction to Fowler syndrome.

bioRxiv · Oct 3, 2023Biochemistry

Mfsd7b facilitates choline uptake and missense mutations affect choline transport function

T. T. H. Ha, V. K. Sukumar, J. W. B. Chua, D. T. Nguyen, T. Q. Nguyen, L. H. K. Lim, A. Cazenave-Gassiot, L. N. Nguyen

This study identifies MFSD7b as a choline transporter and shows that missense mutations impair its function.

bioRxiv · Sep 30, 2023 · PreprintBiochemistry

Structural and mechanistic insights into human choline and ethanolamine transport

K. Ri, T.-H. Weng, A. Claveras Cabezudo, W. Jösting, Z. Yu, A. Bazzone, N. C. P. Leong, S. Welsch, R. T. Doty, G. Gursu, T. J. Y. Lim, S. L. Schmidt, J. L. Abkowitz, G. Hummer, D. Wu, , S. Safarian

This study identifies FLVCR1 and FLVCR2 as choline and ethanolamine transporters, revealing their structural dynamics and substrate selectivity mechanisms.

bioRxiv · Sep 15, 2023 · PreprintBiophysics

SPNS1 is required for the transport of lysosphingolipids and lysoglycerophospholipids from lysosomes

H. T. T. Ha, X. T. A. Nguyen, L. K. Vo, N. C. P. Leong, S. Liu, D. T. Nguyen, Y. P. Lim, J. Y. Wu, T. Q. Nguyen, J. Oh, M. R. Wenk, A. Cazenave-Gassiot, Y. W. Ong, L. N. Nguyen

This study identifies SPNS1 as a lysosomal transporter critical for exporting lysosphingolipids and lysoglycerophospholipids, linking its deficiency to lysosomal storage disease-like pathology.

bioRxiv · Dec 14, 2022 · PreprintBiochemistry

CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

G. Yi, A. Mandoli, L. Jussen, E. Tijchon, G. Cordonnier, M. Hansen, B. Kim, L. N. Nguyen, P. Jansen, M. Vermeulen, E. van den Akker, J. Bond, J. H. A. Martens

This study shows that the CBFβ-MYH11 fusion protein inhibits megakaryocyte differentiation by disrupting the GATA2 and KLF1 gene program in inv(16) AML cells.

bioRxiv · Oct 29, 2018Cancer Biology