Kv7.2 Loss-of-Function Causes Early Hyperexcitability and Network Remodeling
Nina Dirkx, Mark D. Kaji, Els De Vriendt, Giusy Carleo, Francesco Miceli, Bob Asselbergh, Peter Verstraelen, Noortje Zonnekein, Luciano Carotenuto, Louis T. Dang, Vera Sommers, E. Vlaemynck, Lieven Lagae, Berten Ceulemans, Peter De Jonghe, , Sarah Weckhuysen
This study shows that KCNQ2 loss-of-function causes early hyperexcitability and network remodeling in human neurons, with biphasic changes in function, gene expression, and structure.
bioRxiv · Jul 22, 2025 · PreprintNeuroscience