Louis T. Dang

This study shows STRADA deficiency reduces cortical inhibitory interneurons and increases striatal interneurons in mice and a human PMSE brain, suggesting impaired interneuron migration contributes to the disorder.

This study shows RAI1 deficiency accelerates human neurodevelopmental gene expression and disrupts lineage programs in neural progenitors.

The paper identifies RNU2-2 variants as a frequent cause of neurodevelopmental disorders, both dominant and recessive, in a large cohort of individuals with rare disorders.

This study shows that mTOR hyperactivity in STRADA-deficient brain organoids causes delayed neurogenesis and altered interneuron fate, which can be rescued by rapamycin.

EpiPred improves STXBP1 variant interpretation, enabling precision genetic diagnoses and promoting access to targeted precision therapies.

This study shows that KCNQ2 loss-of-function causes early hyperexcitability and network remodeling in human neurons, with biphasic changes in function, gene expression, and structure.

This paper develops a knock-in rabbit model of LQT2 with KCNH2 deletion, showing prolonged QT intervals, seizures, and sudden death similar to human LQT2.

This paper demonstrates that vitrification can effectively cryopreserve human cortical organoids, maintaining their structure, cell type composition, and function.

MonaGO provides an interactive web-based visualization system for gene ontology enrichment analysis, offering dynamic clustering and customizable outputs to improve interpretation of results.