Peter Verstraelen

Kv7.2 Loss-of-Function Causes Early Hyperexcitability and Network Remodeling

This study shows that KCNQ2 loss-of-function causes early hyperexcitability and network remodeling in human neurons, with biphasic changes in function, gene expression, and structure.

DRP1 depletion protects NK cells against hypoxia-induced dysfunction

This study shows that DRP1 depletion protects NK cells from hypoxia-induced dysfunction by preserving mitochondrial function and cytotoxic activity.

S100A8-enriched microglia populate the brain of tau-seeded and accelerated aging mice

The paper identifies S100A8-enriched microglia in tauopathy and accelerated aging mouse models, showing their presence in human AD and tauopathy biopsies.

Enteric glia adopt an activated pro-inflammatory state in response to human and bacterial amyloids

The paper investigates how human and bacterial amyloids affect enteric glia and smooth muscle cells, finding they trigger a pro-inflammatory response and DNA damage.

Systematic quantification of synapses in primary neuronal culture

The paper develops a proximity ligation-based method to improve synapse quantification in neuronal cultures by reducing false positives and increasing sensitivity.

Deep coverage microscopy exposes a pharmacological window for modifiers of neuronal network connectivity

The paper develops a microscopy-based pipeline to quantify neuronal network connectivity and identifies compounds that enhance connectivity and provide neuroprotection.

Single-cell and neuronal network alterations in an in vitro model of Fragile X syndrome

This study examines how the absence of FMRP affects neuronal network development in an in vitro model, finding that network-level changes are more pronounced than single-cell alterations.