Author

Nina Dirkx

University of AntwerpORCID 0000-0002-7193-1123Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Els De VriendtiD· 2 shared Sarah WeckhuyseniD· 2 shared Berten CeulemansiD· 1 shared Bob AsselberghiD· 1 shared Bobby P.C. KoelemaniD· 1 shared E. Vlaemynck· 1 shared Francesco MiceliiD· 1 shared Giusy CarleoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Els De VriendtORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintJul 22, 2025

Kv7.2 Loss-of-Function Causes Early Hyperexcitability and Network Remodeling

Nina Dirkx, Mark D. Kaji, Els De Vriendt…·Sarah Weckhuysen

This study shows that KCNQ2 loss-of-function causes early hyperexcitability and network remodeling in human neurons, with biphasic changes in function, gene expression, and structure.

DOI 10.1101/2025.07.22.664856

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintMay 4, 2022

Efficient and accurate prime editing strategy to correct genetic alterations in hiPSC using single EF-1alpha driven all-in-one plasmids

Wout J. Weuring, Nina Dirkx, Els De Vriendt…·Bobby P.C. Koeleman

This study develops and tests novel all-in-one plasmids for prime editing in hiPSC, achieving up to 50% edit efficiency with reduced off-target effects.

3 citations

humanCRISPR screen

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