Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: A feedback inhibition mechanism of the menaquinone biosynthesis pathway
T. Stanborough, N. A. T. Ho, E. M. M. Bulloch, G. Bashiri, S. S. Dawes, E. W. Akazong, J. Titterington, T. M. Allison, W. Jiao, J. M. Johnston
This study shows that DHNA allosterically inhibits Sau-MenD, a key enzyme in MK biosynthesis, and demonstrates conserved feedback inhibition in Staphylococcus aureus.
bioRxiv · Jul 12, 2022Biochemistry