Author

E. W. Lake

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Biophysics· 1

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Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

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A. Thompson· 1 shared D. D. Thomas· 1 shared E. F. Ruff· 1 shared J. D. Chodera· 1 shared J. M. Behr· 1 shared J. M. Muretta· 1 shared N. M. Levinson· 1 shared S. Cyphers· 1 shared

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2017-2017 · peak 1/yr

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1 shared paperBiophysics

A. Thompson

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1 paper

Recent·Most cited

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

E. F. Ruff, J. M. Muretta, A. Thompson, E. W. Lake, S. Cyphers, S. K. Albanese, S. M. Hanson, J. M. Behr, D. D. Thomas, J. D. Chodera, N. M. Levinson

This study shows that phosphorylation of Aurora A's activation loop activates the kinase without shifting the DFG-In state population, and that a DFG-Out subpopulation is important for optimized substrate binding kinetics.

bioRxiv · Oct 18, 2017Biophysics