Author

J. M. Behr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. D. Chodera· 2 shared N. M. Levinson· 2 shared S. K. Albanese· 2 shared S. M. Hanson· 2 shared A. Solovyov· 1 shared A. Thompson· 1 shared A. W. Drong· 1 shared B. D. Greenbaum· 1 shared

Activity by Year

2016-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

J. D. Chodera

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Author profile →

3 papers

Recent·Most cited

Mechanism-guided quantification of LINE-1 reveals p53 regulation of both retrotransposition and transcription

A. Solovyov, J. M. Behr, D. Hoyos, E. M. Banks, A. W. Drong, J. Z. Zhong, E. Garcia-Rivera, W. McKerrow, C. Chu, D. M. Zaller, M. Fromer, B. D. Greenbaum

This study quantifies LINE-1 retrotransposition and expression in cancer, showing TP53 mutations enable retrotransposition by disinhibiting L1 expression and enabling reintegration.

bioRxiv · May 11, 2023 · PreprintCancer Biology

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

E. F. Ruff, J. M. Muretta, A. Thompson, E. W. Lake, S. Cyphers, S. K. Albanese, S. M. Hanson, J. M. Behr, D. D. Thomas, J. D. Chodera, N. M. Levinson

This study shows that phosphorylation of Aurora A's activation loop activates the kinase without shifting the DFG-In state population, and that a DFG-Out subpopulation is important for optimized substrate binding kinetics.

bioRxiv · Oct 18, 2017Biophysics

An open library of human kinase domain constructs for automated bacterial expression

S. K. Albanese, D. L. Parton, M. Isık, L. Rodriguez-Laureano, S. M. Hanson, J. M. Behr, S. Gradia, C. Jeans, N. M. Levinson, M. A. Seeliger, J. D. Chodera

This paper presents a library of 52 human kinase domain constructs expressed in bacteria using phosphatase coexpression, enabling high-throughput biochemical and biophysical studies.

bioRxiv · Feb 25, 2016Biochemistry