S. K. Albanese

The paper identifies a mutation in Abl kinase that causes imatinib resistance through altered drug dissociation kinetics rather than reduced binding affinity.

This study evaluates the accuracy of predicting compound selectivity using free energy calculations for kinase inhibitors, finding that systematic errors correlate between targets and longer simulations improve selectivity prediction.

This study identifies Ro 08-2750 as a small molecule that targets MSI2 RNA-binding activity, inducing differentiation, apoptosis, and reduced disease burden in AML models.

This paper uses alchemical free-energy calculations to predict how Abl mutations affect inhibitor affinity, achieving accurate results for clinical mutations.

This study shows that phosphorylation of Aurora A's activation loop activates the kinase without shifting the DFG-In state population, and that a DFG-Out subpopulation is important for optimized substrate binding kinetics.

This paper presents a library of 52 human kinase domain constructs expressed in bacteria using phosphatase coexpression, enabling high-throughput biochemical and biophysical studies.