Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures
Aleksandra Binek, Johannes V. Janssens, Niveda Sundararaman, Yaqun Teng, Kim M. Mellor, Antonia J. A. Raaijmakers, Claire L. Curl, Lizhuo Ai, Lawrence S.C. Czer, Amy D Bradshaw, Kavita Sharma, Virginia S. Hahn, Kenneth S. Campbell, Michael R. Zile, David A. Kass, , Jennifer E. Van Eyk
This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.
bioRxiv · Dec 20, 2025 · PreprintMolecular Biology