This paper develops a platform combining robotic proteomics and AI to enable scalable drug mechanism discovery through high-throughput data analysis and hypothesis generation.

bioRxiv · May 7, 2026 · PreprintSystems Biology

Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures

Aleksandra Binek, Johannes V. Janssens, Niveda Sundararaman, Yaqun Teng, Kim M. Mellor, Antonia J. A. Raaijmakers, Claire L. Curl, Lizhuo Ai, Lawrence S.C. Czer, Amy D Bradshaw, Kavita Sharma, Virginia S. Hahn, Kenneth S. Campbell, Michael R. Zile, David A. Kass, , Jennifer E. Van Eyk

This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.

bioRxiv · Dec 20, 2025 · PreprintMolecular Biology

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons

Jennifer T. Stocksdale, Matthew Joseph Leventhal, Stephanie Lam, Yuxin Xu, Yi Wang, Keona Q. Wang, Reuben Thomas, Zohreh Faghihmonzavi, Yogindra Raghav, Charlene Smith-Geater, Jie Wu, Ricardo Miramontes, Kanchan Sarda, Heather Johnston, Min‐Gyoung Shin, , Leslie Michels Thompson

This study compares the effects of HTT knockout and CAG repeat expansion in cortical neurons, identifying shared and distinct biological pathways involved in HD.

Neurobiology of Disease · Apr 19, 2025Peer-reviewedCell Biology

Paradigm shift in biomarker translation: a pipeline to generate clinical grade biomarker candidates from DIA-MS discovery

Qin Fu, Manasa Vegesna, Niveda Sundararaman, Eugen Damoc, Tabiwang N. Arrey, Anna Pashkova, Emebet Mengesha, Philip Debbas, Sandy Y. Joung, Dalin Li, Susan C. Cheng, Jonathan G. Braun, Dermot P.B. McGovern, Christopher I. Murray, Yue Xuan, Jennifer E. Van Eyk

This paper introduces TEAQ, a software tool that selects clinical-grade biomarker candidates from DIA-MS data by evaluating protein quantification metrics in a discovery cohort.

Angewandte Chemie · Oct 21, 2024Peer-reviewedBiochemistry

Identification of Disease-relevant, Sex-based Proteomic Differences in iPSC-derived Vascular Smooth Muscle

Nethika R. Ariyasinghe, Divya Gupta, Sean Escopete, Aleksandr B. Stotland, Niveda Sundararaman, Ben Ngu, Kruttika Dabke, Deepika Rai, Liam McCarthy, Roberta de Souza Santos, Megan Laura McCain, Dhruv Sareen, Sarah J. Parker

This study identifies sex-based proteomic differences in iPSC-derived vascular smooth muscle cells and their potential impact on cardiovascular disease.

The FASEB Journal · May 1, 2022Peer-reviewedMolecular Biology