Aleksandra Binek

This study investigates the role of fast skeletal myosin binding protein-C in heart failure, finding that its expression exacerbates cardiac dysfunction and that its deletion improves heart function.

This paper introduces an enhanced single-cell proteomics workflow using timsUltra AIP, showing improved proteome coverage and drug response subtyping in human iPSC-CMs.

The paper reports single-cell proteomic maps of human iPSCs and their differentiation into motor neurons, revealing proteomic and transcriptomic discordance.

This study introduces a shotgun single-cell top-down proteomics method to profile proteoform diversity in cardiomyocytes, revealing significant molecular heterogeneity across individual cells.

The paper introduces an algorithm called GoldenHaystack that improves peptide quantification in DIA-MS data by quantifying previously unquantified peptides and achieving faster runtime.

This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.

This study adapts high-field asymmetric ion mobility spectrometry (FAIMS) coupled with mass spectrometry to improve cardiac muscle proteome coverage with reduced sample handling and processing time compared to traditional methods.

This paper identifies key transcription and translation regulators affected by CDC treatment in rat HFpEF, correlating their levels with diastolic function improvements.

The paper introduces a method to quantify lysine and arginine PTMs in NASH using mass spectrometry and applies it to mouse liver lysates, finding altered methylation and acetylation in NASH.