Author

Johannes V. Janssens

Cedars-Sinai Medical CenterORCID 0000-0002-7494-7702Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:organoid / primary culture· 1

Frequent Co-Authors

Jennifer E. Van EykiD· 4 shared Antonia J. A. RaaijmakersiD· 3 shared Claire L. CurliD· 3 shared Lea M.D. DelbridgeiD· 3 shared Aleksandr B. StotlandiD· 2 shared Aleksandra BinekiD· 2 shared DAVID J. TAYLORiD· 2 shared Enzo R. PorrelloiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMolecular Biology

Jennifer E. Van EykORCID

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4 papers

Recent·Most cited

Expanded Proteome Coverage Powered by Advanced Ion Processing Enables Deep Single-Cell Drug Response Subtyping in Human Stem Cell Derived Cardiomyocytes

Johannes V. Janssens, Aleksandra Binek, Lizhuo Ai, Ajay Bhardwaj, Madelyn Arzt, Diego Assis, Matthew Willetts, Michael Krawitzky, Daniel Hornburg, Arun Sharma, Aleksandr B. Stotland, Jennifer E. Van Eyk

This paper introduces an enhanced single-cell proteomics workflow using timsUltra AIP, showing improved proteome coverage and drug response subtyping in human iPSC-CMs.

bioRxiv · May 31, 2026 · PreprintMolecular Biology

Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures

Aleksandra Binek, Johannes V. Janssens, Niveda Sundararaman, Yaqun Teng, Kim M. Mellor, Antonia J. A. Raaijmakers, Claire L. Curl, Lizhuo Ai, Lawrence S.C. Czer, Amy D Bradshaw, Kavita Sharma, Virginia S. Hahn, Kenneth S. Campbell, Michael R. Zile, David A. Kass, , Jennifer E. Van Eyk

This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.

bioRxiv · Dec 20, 2025 · PreprintMolecular Biology

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Marco Annandale, X. Li, Samuel L. James, DAVID J. TAYLOR, Koen Raedschelders, Kate L. Weeks, Richard J. Mills, , Lea M.D. Delbridge

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

Nature Cardiovascular Research · Sep 29, 2025Peer-reviewedPhysiology

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Victoria L. Benson, E. Chan, Marco Annandale, Xun Li, Yohanes N. S. Nursalim, Wendy T.K. Ip, David J. Taylor, , Lea M.D. Delbridge

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

bioRxiv · Jun 21, 2021 · PreprintMolecular Biology