Author

Claire L. Curl

The University of MelbourneORCID 0000-0002-8092-9236Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Antonia J. A. RaaijmakersiD· 3 shared Jennifer E. Van EykiD· 3 shared Johannes V. JanssensiD· 3 shared Lea M.D. DelbridgeiD· 3 shared DAVID J. TAYLORiD· 2 shared Enzo R. PorrelloiD· 2 shared Gabriel B. BernasochiiD· 2 shared James E. HudsoniD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Antonia J. A. RaaijmakersORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multicenter HFpEF study identifies sex disparity linked with two discrete cardiac proteomic signatures

Aleksandra Binek, Johannes V. Janssens, Niveda Sundararaman, Yaqun Teng, Kim M. Mellor, Antonia J. A. Raaijmakers, Claire L. Curl, Lizhuo Ai, Lawrence S.C. Czer, Amy D Bradshaw, Kavita Sharma, Virginia S. Hahn, Kenneth S. Campbell, Michael R. Zile, David A. Kass, , Jennifer E. Van Eyk

This study identifies two distinct cardiac proteomic signatures in HFpEF linked to sex ratios, revealing molecular differences in structural machinery and cellular communication.

bioRxiv · Dec 20, 2025 · PreprintMolecular Biology

Targeted glycophagy ATG8 therapy reverses diabetic heart disease in mice and in human engineered cardiac tissues

Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Marco Annandale, X. Li, Samuel L. James, DAVID J. TAYLOR, Koen Raedschelders, Kate L. Weeks, Richard J. Mills, , Lea M.D. Delbridge

This study identifies glycophagy dysregulation as a mechanism of diabetic heart disease and shows that Gabarapl1 gene therapy improves cardiac function in diabetic mice and human cardiac organoids.

Nature Cardiovascular Research · Sep 29, 2025Peer-reviewedPhysiology

Protective role of the Atg8 1 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease

Kimberley M. Mellor, Upasna Varma, Parisa Koutsifeli, Claire L. Curl, Johannes V. Janssens, Lorna J. Daniels, Gabriel B. Bernasochi, Antonia J. A. Raaijmakers, Victoria L. Benson, E. Chan, Marco Annandale, Xun Li, Yohanes N. S. Nursalim, Wendy T.K. Ip, David J. Taylor, , Lea M.D. Delbridge

This study identifies Gabarapl1 as a regulator of glycophagy in diabetic cardiomyopathy, showing its role in preventing glycogen accumulation and diastolic dysfunction.

bioRxiv · Jun 21, 2021 · PreprintMolecular Biology