Short prokaryotic Argonautes provide defence against invading mobile genetic elements through NAD+ depletion
Mindaugas Zaremba, Donata Dakineviciene, Edvardas Golovinas, Evelina Zagorskaitė, Edvinas Stankunas, Anna Lopatina, Rotem Sorek, E. Manakova, Audronė Rukšėnaitė, Arūnas Šilanskas, Simonas Ašmontas, Algirdas Grybauskas, Ugnė Tylenytė, Edvinas Jurgelaitis, Rokas Grigaitis, , Virginijus Šikšnys
The paper shows short prokaryotic Argonautes, when associated with Sir2, deplete NAD+ to defend against invading DNA.
Nature Microbiology · Oct 3, 2022Peer-reviewedMolecular Biology