Activation of SPARDA defense system by filament assembly reveals beta-relay signaling mechanism widespread in prokaryotic Argonautes
Edvinas Jurgelaitis, Evelina Zagorskaitė, Aurimas Kopūstas, Simonas Ašmontas, E. Manakova, Indrė Dalgėdienė, Ugnė Tylenytė, Arūnas Šilanskas, Paulius Toliusis, Algirdas Grybauskas, Marijonas Tutkus, Česlovas Venclovas, Mindaugas Zaremba
The paper reveals a beta-relay signaling mechanism in prokaryotic Argonautes that activates the SPARDA defense system to degrade invading DNA and host DNA, preventing plasmid spread.
bioRxiv · Apr 8, 2025 · PreprintBiochemistry