Česlovas Venclovas

This study identifies Csx15 as a ring nuclease that degrades cyclic nucleotides from both CRISPR-Cas and CBASS systems, revealing its role in regulating signaling pathways.

The paper reveals a beta-relay signaling mechanism in prokaryotic Argonautes that activates the SPARDA defense system to degrade invading DNA and host DNA, preventing plasmid spread.

This paper develops a protocol to predict protein complex structures using diversified AlphaFold models and a new scoring method, achieving top results in CASP15.

VoroIF-GNN assesses protein-protein interface accuracy using a graph neural network based on Voronoi tessellation, showing strong performance in CASP15.

The paper shows short prokaryotic Argonautes, when associated with Sir2, deplete NAD+ to defend against invading DNA.

The paper introduces VoroCNN, a deep convolutional neural network for predicting local qualities of 3D protein folds using Voronoi tessellation, achieving competitive results compared to existing methods.