Enhancing the iNKT cell immunotherapy platform by combining optimised CAR endodomains with novel iNKT engagers
Kanagaraju Ponnusamy, Klesti Karaxhuku, Yang Jiang, Lyra O. Randzavola, Hongwei Ren, Ilia Leontari, Bryan Lye, Mehmood Zaidi, Edward J Bartlett, Edward W. Tate, Vasileios Pardalis, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Rogier M. Reijmers, , Anastasios Karadimitris
This study enhances iNKT cell immunotherapy by combining optimized CAR endodomains with novel iNKT-specific engagers to improve anti-myeloma activity.
bioRxiv · Oct 23, 2025 · PreprintImmunology