Author

Kanagaraju Ponnusamy

Imperial College LondonORCID 0000-0002-6618-9104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Anastasios KaradimitrisiD· 2 shared Bryan LyeiD· 2 shared Hongwei ReniD· 2 shared Ilia LeontariiD· 2 shared Irene A.G. RobertsiD· 2 shared Alexia Katsarou· 1 shared Anindita RoyiD· 1 shared Aristeidis ChaidosiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersImmunology

Anastasios KaradimitrisORCID

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2 papers

Recent·Most cited

Enhancing the iNKT cell immunotherapy platform by combining optimised CAR endodomains with novel iNKT engagers

Kanagaraju Ponnusamy, Klesti Karaxhuku, Yang Jiang, Lyra O. Randzavola, Hongwei Ren, Ilia Leontari, Bryan Lye, Mehmood Zaidi, Edward J Bartlett, Edward W. Tate, Vasileios Pardalis, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Rogier M. Reijmers, , Anastasios Karadimitris

This study enhances iNKT cell immunotherapy by combining optimized CAR endodomains with novel iNKT-specific engagers to improve anti-myeloma activity.

bioRxiv · Oct 23, 2025 · PreprintImmunology

Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease

Hongwei Ren, Natalina Elliott, Bryan Lye, Mohammad Umer Sharif Shohan, Joe W. Cross, Lucy May Field, Kanagaraju Ponnusamy, Siobhan Rice, Thomas Jackson, Ilia Leontari, Nouhad El Ouazzani, Rebecca Thomas, Sarah Inglott, Jack Luke Bartram, Owen Patrick Smith, , Anastasios Karadimitris

This paper develops bi-specific CAR-iNKT cells targeting CD19 and CD133 for KMT2A-rearranged leukemia, showing superior efficacy over CAR-T in eradicating leptomeningeal disease and inducing remission.

bioRxiv · Jan 22, 2025 · PreprintCancer Biology