Yingping Hou

This study uses snRNA-seq and a new method called GO-TEN to analyze mosaic genetic variants in focal cortical dysplasia, revealing cell-autonomous and non-cell-autonomous transcriptional changes associated with epilepsy.

The paper maps long-range enhancer networks in human, macaque, and mouse fetal cortex, showing human-specific enhancers and neuropsychiatric disorder-linked SNPs regulate gene expression during neurogenesis.

This study uses super-resolution imaging to show that replication origins are preferentially fired at the periphery of TADs due to chromatin re-organization linked to transcription and CTCF.

The paper characterizes 3D genome structure and chromatin accessibility in human tolerant T cells, identifying SOCS1 as a key regulator of tolerance.

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

This study investigates the role of lamin B1 in chromatin architecture and dynamics using imaging and Hi-C sequencing, finding that lamin B1 depletion leads to chromatin decompaction and increased inter-chromosomal interactions.

This paper introduces a vector-independent method for multiplexed sgRNA expression, enabling efficient and scalable single non-repetitive DNA labeling and gene regulation in live cells.