Expansion of a bacterial operon during cancer treatment ameliorates drug toxicity
Kai R. Trepka, Wesley Allen Kidder, Than S. Kyaw, Taylor Halsey, C. Anders Olson, Edwin F. Ortega, Cecilia A. Noecker, Vaibhav Upadhyay, Dalila Stanfield, Paige Steiding, Benjamin G. H. Guthrie, Peter Spanogiannopoulos, Darren S. Dumlao, Jessie A. Turnbaugh, Matthew D. Stachler, , Peter James Turnbaugh
The paper shows that a bacterial operon in the gut microbiome can reduce drug toxicity during cancer treatment by inactivating 5-fluorouracil.
bioRxiv · Jun 4, 2024 · PreprintSystems Biology